Emerging Challenges in Multiscale Modeling in Biology.

Emerging Challenges in Multiscale Modeling in Biology Roy Kerckhoffs

Investigation of Vacancy Defects on the Young’s Modulus of Carbon Nanotube Reinforced Composites in Axial Direction via a Multiscale Modeling Approach

In this article, the influence of various vacancy defects on the Young’s modulus of carbon nanotube (CNT) - reinforcement polymer composite in the axial direction is investigated via a structural model in ANSYS software. Their high strength can be affected by the presence of defects in the nanotubes used as reinforcements in practical nanocomposites. Molecular structural mechanics (MSM)/finite ...

Special issue on Modeling and Control in Social Dynamics

This Special Issue is based on research presented at the Workshop “Modeling and Control of Social Dynamics”, hosted by the Center of Computational and Integrative Biology and the Department of Mathematical Sciences at Rutgers University Camden. The Workshop is part of the activities of the NSF Research Network in Mathematical Sciences: “Kinetic description of emerging challenges in multiscale p...

Towards A Generic Supporting Environment For Multiscale Modelling

Multiscale modelling as an emerging modelling paradigm is now widely regarded as a promising and powerful tool in various disciplines. However, a multiscale model is usually much more difficult to develop than a single-scale model due to a range of challenges. This work presents a methodology to facilitate the development of multiscale models, which comprises three main modelling steps, namely ...

Integrative Systems Models of Cardiac Excitation–Contraction Coupling Alternans and Arrhythmias: From Cells to the Heart Computational Models Reduce Complexity and Accelerate Insight Into Cardiac Signaling Networks Whole Heart Modeling: Applications to Cardiac Electrophysiology and Electromechanics

Excitation–contraction coupling in the cardiac myocyte is mediated by a number of highly integrated mechanisms of intracellular Ca transport. The complexity and integrative nature of heart cell electrophysiology and Ca cycling has led to an evolution of computational models that have played a crucial role in shaping our understanding of heart function. An important emerging theme in systems bio...